Open AccessEffect of Exogenous Interleukin-18 (IL-18) and IL-12 in the Course ofBrucella abortus2308 Infection in Mice
Author(s) -
Paolo Pasquali,
Rosanna Adone,
Louis C. Gasbarre,
Claudia Pistoia,
F. Ciuchini
Publication year - 2002
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cdli.9.2.491-492.2002
Subject(s) - brucella abortus , brucella , immunology , course (navigation) , interleukin , interleukin 4 , interleukin 15 , brucellosis , interleukin 1β , microbiology and biotechnology , biology , cytokine , physics , astronomy
In this study we demonstrated that combined inoculation of interleukin-12 (IL-12) and IL-18 reduced the number of bacteria in the spleens of mice infected with Brucella abortus 2308 and that the effect of the treatment was mediated by an increased capability of spleen cells to produce gamma interferon at the early phase of infection.
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