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The expression of CD25 and CD45RO in lymphocytes from patients with acute lymphoblastic leukemia in response to cytomegalovirus and varicella-zoster virus antigens was analyzed by flow cytometry. It is suggested that the defects in the immune response to cytomegalovirus and varicella-zoster virus in patients with acute lymphoblastic leukemia on chemotherapy are in the expression of CD25 and in the switching of CD45RA cells to CD45RO cells.

clinical and diagnostic laboratory immunology

Impaired expression of interleukin 2 receptor and CD45RO antigen on lymphocytes from children with acute lymphoblastic leukemia in response to cytomegalovirus and varicella-zoster virus