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CD4(+) CD25(+) T cells are a population of regulatory T cells associated with control of arthritis in anti-interleukin-17 antibody-treated Borrelia-vaccinated and challenged gamma interferon-deficient mice. Here, we present direct evidence that adoptive transfer of enriched CD4(+) CD25(+) T cells from these mice can prevent the development of arthritis in Borrelia-vaccinated and challenged mice. These findings establish a major role for CD4(+) CD25(+) T cells in the prevention of arthritis in Borrelia-vaccinated and challenged animals.

CD4 + CD25 + T Cells Prevent Arthritis Associated with Borrelia Vaccination and Infection

CD4 ⁺ CD25 ⁺ T Cells Prevent Arthritis Associated with Borrelia Vaccination and Infection