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The expression of the CD69 antigen on CD4 T lymphocytes after in vitro stimulation with purified protein derivative (2 tuberculin units) was used to evaluate the tuberculin reactivities of 52 individuals from four experimental groups: Mycobacterium bovis BCG-vaccinated healthy individuals with a negative tuberculin skin test (TST) result (group A), BCG-vaccinated healthy individuals with a positive TST result (group B), patients with active tuberculosis (TB) before treatment (group C), and individuals with clinically inactive TB who had previously completed a prescribed course of chemotherapy (group D). The expression of CD69 on CD4 T lymphocytes was significantly higher in patients with active TB (16.2%+/-7.3%), individuals with clinically inactive TB (10.5%+/-7.4%), and healthy individuals with a positive TST result (15.5%+/-7.2%) than in healthy individuals with a negative TST result (3.8%+/-4.3%) (P&lt;0.005). We confirmed the correlation between CD69 antigen expression on T lymphocytes after stimulation with tuberculin and the TST induration diameter (Spearman rho=0.783; P&lt;0.001), an assay for gamma interferon (the Quantiferon-TB assay; Spearman rho=0.613; P&lt;0.001), and the lymphocyte BLAST transformation test (Spearman rho=0.537; P&lt;0.001). Our results demonstrate the usefulness of the determination of CD69 on CD4 T lymphocytes after in vitro stimulation with tuberculin as a rapid indicator of immune sensitization against Mycobacterium tuberculosis.

clinical and vaccine immunology

CD69 Expression on CD4<sup>+</sup>T Lymphocytes after In Vitro Stimulation with Tuberculin Is an Indicator of Immune Sensitization against<i>Mycobacterium tuberculosis</i>Antigens

CD69 Expression on CD4+T Lymphocytes after In Vitro Stimulation with Tuberculin Is an Indicator of Immune Sensitization againstMycobacterium tuberculosisAntigens

CD69 Expression on CD4⁺T Lymphocytes after In Vitro Stimulation with Tuberculin Is an Indicator of Immune Sensitization againstMycobacterium tuberculosisAntigens