Open AccessEffects of Hypothermia on Mortality and Inflammatory Responses to Endotoxin-Induced Shock in Rats
Author(s) -
Takumi Taniguchi,
Hiroko Kanakura,
Y. Takemoto,
Ken Yamamoto
Publication year - 2003
Publication title -
clinical and vaccine immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.649
H-Index - 77
eISSN - 1556-6811
pISSN - 1556-679X
DOI - 10.1128/cdli.10.5.940-943.2003
Subject(s) - hypothermia , tumor necrosis factor alpha , nitric oxide , shock (circulatory) , medicine , cytokine , pharmacology , mortality rate , anesthesia , immunology
We studied the effects of hypothermia on mortality rate, concentrations of tumor necrosis factor alpha and interleukin 6 in plasma, and the end products of nitric oxide (NO) in endotoxemia. It was found that moderate and mild hypothermia improved the mortality rate and attenuated cytokine responses and the elevation of the end products of NO after endotoxin injection and that these beneficial effects were similar for moderate and mild hypothermia.
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