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It has been postulated that 3-(3-oxo-7α-methylthio-4-androsten-17α-yl)propionic acid γ-lactone (I) is a key intermediate in the metabolism of the anti-aldosterone agent, spironolactone (3-[3-oxo-7α-acetylthio-17β-hydroxy-4-androsten-17α-yl] propionic acid γ-lactone). In the present study it was found that microbial oxygenation of I byChaetomium cochloides QM 624 gave three metabolites which retained sulfur in their molecules and were found to be identical to the human metabolites of spironolactone.

Preparation of Metabolites of Spironolactone by Microbial Oxygenation