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Melnykowycz and Johansson (1955) have shown that chlortetracycline suppresses amino acid decarboxylation by intestinal microorganisms in the rat, formation of lysine decarboxylase in Escherichia coli, and decarboxylation of tyrosine in Streptococcus faecalis R. These workers postulate that antibiotics reduce enterotoxemia and improve growth by inhibiting amine formation in the intestine. Since vitamin B6 is the cofactor of the amino acid decarboxylase enzymes, the present work was undertaken to determine the effect of chlortetracycline (CTC) on vitamin B6 utilization and amino acid decarboxylation in chicks.

Effect of Chlortetracycline on Vitamin B6 and Amino Acid Decarboxylase in Bacteria from the Alimentary Tract of the Chick