Open AccessFormation of Dimethylmuconolactones from Dimethylphenols by Alcaligenes eutrophus JMP 134
Author(s) -
D H Pieper,
Karin Stadler-Fritzsche,
HansJoachim Knackmuss,
K. N. Timmis
Publication year - 1995
Publication title -
applied and environmental microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.552
H-Index - 324
eISSN - 1070-6291
pISSN - 0099-2240
DOI - 10.1128/aem.61.6.2159-2165.1995
Subject(s) - hydroxylation , cleavage (geology) , biotransformation , stereochemistry , chemistry , alcaligenes , metabolic pathway , biochemistry , biology , enzyme , bacteria , genetics , fracture (geology) , paleontology , pseudomonas
2,3-, 2,4-, 2,5-, 3,4-, and 3,5-dimethylphenols were cometabolized by 2,4-dichlorophenoxyacetate-grown Alcaligenes eutrophus JMP 134 or the constitutive derivative JMP 134-1 via the ortho pathway into dimethylmuconolactones as dead-end products. Formation of two distinct lactones from 3,4-dimethylphenol is indicative of 2- as well as 6-hydroxylation. Induction of the meta-cleavage pathway by 2,3- and 3,4-dimethylphenols resulted in growth and no accumulation of products. In contrast, 3,5-dimethylphenol is not metabolized by the meta-cleavage pathway.
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