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Selective growth inhibitors ofSphaerotilus natans were detected in the culture broths of several strains ofStreptomyces . Anslimins A and B were isolated from the culture broth ofStreptomyces oganonensis by adsorption on resinous adsorbent followed by elution with 50% aqueous acetone. The A and B components were then separated by cellulose powder chromatography. Physicochemical parameters of anslimins A and B revealed that these compounds are new peptide-containing structures. Anslimins A and B inhibited growth ofS. natans at 0.78 and 0.39 μg/ml, respectively, but showed no activity against any of the other test microorganisms at 100 to 200 mg/ml. The anslimins had no harmful effect on guppies at a concentration of 100 mg/liter.

New Selective Growth Inhibitors of Sphaerotilus natans , Anslimins A and B