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M102AD is the new designation for aStreptococcus mutans phage described in 1993 as phage M102. This change was necessitated by the genome analysis of anotherS. mutans phage named M102, which revealed differences from the genome sequence reported here. Additional host range analyses confirmed thatS. mutans phage M102AD infects only a few serotype c strains. Phage M102AD adsorbed very slowly to its host, and it cannot adsorb to serotype e and f strains ofS. mutans . M102AD adsorption was blocked by c-specific antiserum. Phage M102AD also adsorbed equally well to heat-treated and trypsin-treated cells, suggesting carbohydrate receptors. Saliva and polysaccharide production did not inhibit plaque formation. The genome of this siphophage consisted of a linear, double-stranded, 30,664-bp DNA molecule, with a GC content of 39.6%. Analysis of the genome extremities indicated the presence of a 3′-overhangcos site that was 11 nucleotides long. Bioinformatic analyses identified 40 open reading frames, all in the same orientation. No lysogeny-related genes were found, indicating that phage M102AD is strictly virulent. No obvious virulence factor gene candidates were found. Twelve proteins were identified in the virion structure by mass spectrometry. Comparative genomic analysis revealed a close relationship betweenS. mutans phages M102AD and M102 as well as withStreptococcus thermophilus phages. This study also highlights the importance of conducting research with biological materials obtained from recognized microbial collections.

Biology and Genome Sequence of Streptococcus mutans Phage M102AD