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Streptococcus suis strains are classified into 35 serotypes on the basis of the antigenicity of their capsular polysaccharides (CPs). CP synthesis genes are known to be clustered on the chromosome (cps gene cluster). The entirecps gene clusters ofS. suis have so far been sequenced in 15 serotypes and found to be located betweenorfZ andaroA . In this study, to provide comprehensive information aboutS. suis CPs, we sequenced the entirecps gene clusters of the remaining serotypes and analyzed the complete set ofS. suis cps gene clusters. Among the 35cps gene clusters, 22 were located betweenorfZ andaroA , whereas the other 13 were flanked by other gene(s) on the chromosomes, and the chromosomal locus was classified into five patterns. By clustering analysis, the predicted products ofcps genes found in the 35 serotypes were assigned into 291 homology groups, and all serotypes possessed a serotype-specific gene, except for serotypes 1, 2, 1/2, and 14. Because of the presence of genes encoding flippase (wzx ) and polymerase (wzy ), CPs of all serotypes were thought to be synthesized by the Wzx/Wzy pathway. Our data also implied the possibility of the transfer of the entire or partialcps gene clusters amongS. suis strains, as well as the influence of spontaneous mutations in a single gene or a few genes on the antigenicity of some serotypes. Accumulation of these gene transfers and small-scale mutations may have generated the antigenic diversity ofS. suis CPs.

applied and environmental microbiology

Genetic Analysis of Capsular Polysaccharide Synthesis Gene Clusters from All Serotypes of Streptococcus suis: Potential Mechanisms for Generation of Capsular Variation