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Salmonella spp. are an important cause of foodborne illness in North America, and pork products are associated with sporadic cases and outbreaks of human salmonellosis. Isolates ofSalmonella may be resistant to multiple antibiotics, and infections with multidrug-resistant (MDR)Salmonella spp. are more difficult to treat, leading to increased hospitalization rates. Swine operations commonly use antimicrobials, such as chlortetracycline, to prevent/treat infections, which may have collateral effects on pig microbial populations. Recently, we demonstrated that chlortetracycline induces the expression of genes associated with pathogenesis and invasion in MDRSalmonella enterica serovar Typhimuriumin vitro . In our current study, we show increased tonsillar colonization and fecal shedding of the MDRS . Typhimurium strain DT104 from pigs administered chlortetracycline. Therefore, pigs unknowingly colonized with multidrug-resistantSalmonella spp. and receiving chlortetracycline for an unrelated infection may be at a greater risk for disseminating MDRSalmonella spp. to other pigs and to humans through environmental or pork product contamination.

applied and environmental microbiology

Chlortetracycline Enhances Tonsil Colonization and Fecal Shedding of Multidrug-Resistant <i>Salmonella enterica</i> Serovar Typhimurium DT104 without Major Alterations to the Porcine Tonsillar and Intestinal Microbiota

Chlortetracycline Enhances Tonsil Colonization and Fecal Shedding of Multidrug-Resistant Salmonella enterica Serovar Typhimurium DT104 without Major Alterations to the Porcine Tonsillar and Intestinal Microbiota