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Free-living amoebae represent a potential reservoir and predator of Salmonella enterica. Through the use of type III secretion system (T3SS) mutants and analysis of transcription of selected T3SS genes, we demonstrated that the Salmonella pathogenicity island 2 is highly induced during S. enterica serovar Typhimurium infection of Acanthamoeba polyphaga and is essential for survival within amoebae.

applied and environmental microbiology

The <i>Salmonella</i> Pathogenicity Island 2-Encoded Type III Secretion System Is Essential for the Survival of <i>Salmonella enterica</i> Serovar Typhimurium in Free-Living Amoebae

The Salmonella Pathogenicity Island 2-Encoded Type III Secretion System Is Essential for the Survival of Salmonella enterica Serovar Typhimurium in Free-Living Amoebae