Open AccessNeospora caninum Dense Granule Protein 7 Regulates the Pathogenesis of Neosporosis by Modulating Host Immune Response
Author(s) -
Yoshifumi Nishikawa,
Naomi Shimoda,
Ragab M. Fereig,
Tomoya Moritaka,
Kousuke Umeda,
Maki Nishimura,
Fumiaki Ihara,
Kaoru Kobayashi,
Yuu Himori,
Yutaka Suzuki,
Hidefumi Furuoka
Publication year - 2018
Publication title -
applied and environmental microbiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.552
H-Index - 324
eISSN - 1070-6291
pISSN - 0099-2240
DOI - 10.1128/aem.01350-18
Subject(s) - neospora caninum , immune system , biology , pathogenesis , neospora , microbiology and biotechnology , host response , host (biology) , protozoa , virology , immunology , antibody , genetics , toxoplasma gondii
Neospora caninum invades and replicates in a broad range of host species and cells within those hosts. The effector proteins exported byNeospora induce its pathogenesis by modulating the host immunity. We show that most of the transcriptomic effects inN. caninum -infected cells depend upon the activity of NcGRA7. A deficiency in NcGRA7 reduced the virulence of the parasite in mice. This study demonstrates the importance of NcGRA7 in the pathogenesis of neosporosis.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom