Open AccessPotent In Vitro Synergism of Fluconazole and Berberine Chloride against Clinical Isolates of Candida albicans Resistant to Fluconazole
Author(s) -
Huihui Quan,
Yingying Cao,
Zheng Xu,
Jing-Xia Zhao,
PingHui Gao,
Xiaofeng Qin,
Yuanying Jiang
Publication year - 2006
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.50.3.1096-1099.2006
Subject(s) - fluconazole , candida albicans , broth microdilution , microbiology and biotechnology , checkerboard , in vitro , biology , fungi imperfecti , agar , berberine , minimum inhibitory concentration , antifungal , pharmacology , chemistry , antibiotics , bacteria , biochemistry , genetics
In vitro interaction of fluconazole and berberine chloride was investigated against 40 fluconazole-resistant clinical isolates of Candida albicans. Synergism in fungistatic activity was found with the checkerboard microdilution assay. The findings of agar diffusion tests and time-kill curves confirmed the synergistic interaction, but no antagonistic action was observed.
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