Open AccessPentamidine Is Active in a Neutropenic Murine Model of Acute Invasive Pulmonary Fusariosis
Author(s) -
Michail S. Lionakis,
Georgios Chamilos,
Russell E. Lewis,
Nathan P. Wiederhold,
Issam Raad,
George Samonis,
Dimitrios P. Kontoyiannis
Publication year - 2005
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.50.1.294-297.2006
Subject(s) - pentamidine , fusariosis , amphotericin b , neutropenia , pulmonary infection , medicine , biology , chemotherapy , immunology , pharmacology , microbiology and biotechnology , pneumonia , antifungal , horticulture , fusarium
We studied the efficacy of pentamidine (PNT) as prophylaxis or early treatment in acute pulmonary fusariosis in neutropenic mice. PNT-preexposed mice had significantly improved survival and reduced fungal burden compared to amphotericin B-preexposed and untreated mice. PNT-treated mice had increased survival but no difference in fungal burden versus untreated mice.
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