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To study the efficacy of moxifloxacin treatment for tuberculosis, we utilized a novel cartridge system to simulate in vivo pharmacokinetics. We found this system to be a robust method for modeling in vivo pharmacokinetics and present data supporting the utility of intermittent moxifloxacin treatment as a component of antituberculosis chemotherapy.

antimicrobial agents and chemotherapy

Modeling In Vivo Pharmacokinetics and Pharmacodynamics of Moxifloxacin Therapy for <i>Mycobacterium tuberculosis</i> Infection by Using a Novel Cartridge System

Modeling In Vivo Pharmacokinetics and Pharmacodynamics of Moxifloxacin Therapy for Mycobacterium tuberculosis Infection by Using a Novel Cartridge System