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A significant relationship between copper resistance (tcrB), glycopeptide resistance (Tn1546), and macrolide resistance [erm(B)] in Enterococcus faecium isolated from pigs was found. The tcrB gene was located closely upstream of the Tn1546 element. However, the continued use of copper sulfate has not been able to maintain high levels of macrolide and glycopeptide resistance.

antimicrobial agents and chemotherapy

Relationship between Copper, Glycopeptide, and Macrolide Resistance among <i>Enterococcus faecium</i> Strains Isolated from Pigs in Denmark between 1997 and 2003

Relationship between Copper, Glycopeptide, and Macrolide Resistance among Enterococcus faecium Strains Isolated from Pigs in Denmark between 1997 and 2003