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Of 595 isolates of Streptococcus pneumoniae from outpatients with respiratory tract infections, collected from 17 microbiology laboratories, 14.1% were resistant to erythromycin. Eighty-three erythromycin-resistant isolates were genetically analyzed, 83.1% of which harbored the ermB gene. Only four isolates (4.8%) harbored the mefA gene. Telithromycin exhibited potent activity against all isolates.

antimicrobial agents and chemotherapy

High Prevalence of the <i>ermB</i> Gene among Erythromycin-Resistant <i>Streptococcus pneumoniae</i> Isolates in Germany during the Winter of 2000-2001 and In Vitro Activity of Telithromycin

High Prevalence of the ermB Gene among Erythromycin-Resistant Streptococcus pneumoniae Isolates in Germany during the Winter of 2000-2001 and In Vitro Activity of Telithromycin