Open AccessPostantibiotic Effects of Daptomycin against 14 Staphylococcal and Pneumococcal Clinical Isolates
Author(s) -
Glenn A. Pankuch,
Michael R. Jacobs,
Peter C. Appelbaum
Publication year - 2003
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.47.9.3012-3014.2003
Subject(s) - daptomycin , microbiology and biotechnology , streptococcus pneumoniae , staphylococcus aureus , streptococcaceae , micrococcaceae , staphylococcal infections , minimum inhibitory concentration , pneumococcal infections , antibiotics , antibacterial agent , biology , bacteria , vancomycin , genetics
Daptomycin mean staphylococcal postantibiotic effects (PAEs) were 1.1 to 6.2 h, with a mean of 2.5 h. The mean pneumococcal PAEs were 1.7 h, ranging between 1.0 and 2.5 h. The staphylococcal and pneumococcal postantibiotic sub-MIC effects at 0.4 times the MIC ranged from 3.0 to >12.0 h and 1.9 to >12.0 h, respectively.
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