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Six quinolones were tested on 817 consecutive pneumococcal isolates for which ciprofloxacin MICs were high (&gt; or =2 microg/ml); the isolates had been collected during two recent Spanish surveillance studies. For strains for which the ciprofloxacin MIC was &gt;or =4 microg/ml, the MICs at which 90% of the isolates tested against gemifloxacin, moxifloxacin, gatifloxacin, sparfloxacin, levofloxacin, and ofloxacin were inhibited were 0.25, 1, 1, 1, 4 and 16 microg/ml, respectively, and the corresponding prevalences of resistance were 0, 1, 4.5, 9.5, 8.4 and 23%. The proportion of isolates for which the ciprofloxacin MIC is high has increased over time.

antimicrobial agents and chemotherapy

Activities of Six Different Quinolones against Clinical Respiratory Isolates of <i>Streptococcus pneumoniae</i> with Reduced Susceptibility to Ciprofloxacin in Spain

Activities of Six Different Quinolones against Clinical Respiratory Isolates of Streptococcus pneumoniae with Reduced Susceptibility to Ciprofloxacin in Spain