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Amoxicillin at doses of 0.2 to 5 mg/kg of body weight was administered for the treatment of pneumococcal otitis media in a gerbil model. Doses greater than or equal to 2.5 mg/kg, which resulted in concentrations in middle ear fluid of &gt; or = 1.4 microg/ml and concentrations in serum higher than the MIC (1 microg/ml) for &gt; or = 14% of the dosing interval, were both clinically and bacteriologically effective.

Optimal Dose of Amoxicillin in Treatment of Otitis Media Caused by a Penicillin-Resistant Pneumococcus Strain in the Gerbil Model