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Mycoplasma gallisepticum enrofloxacin-resistant mutants were generated by stepwise selection in increasing concentrations of enrofloxacin. Alterations were found in the quinolone resistance-determining regions of the four target genes encoding DNA gyrase and topoisomerase IV from these mutants. This is the first description of such mutations in an animal mycoplasma species.

antimicrobial agents and chemotherapy

Characterization of Mutations in DNA Gyrase and Topoisomerase IV Involved in Quinolone Resistance of <i>Mycoplasma gallisepticum</i> Mutants Obtained In Vitro

Characterization of Mutations in DNA Gyrase and Topoisomerase IV Involved in Quinolone Resistance of Mycoplasma gallisepticum Mutants Obtained In Vitro