Open AccessInfluence of Liposomal Amphotericin B on CD8 T-Cell Function
Author(s) -
Marianne Kretschmar,
Gernot Geginat,
Thomas Bertsch,
Simon Walter,
Herbert Hof,
Thomas Nichterlein
Publication year - 2001
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.45.8.2383-2385.2001
Subject(s) - amphotericin b , dose , pharmacology , in vivo , liposome , cytotoxic t cell , cd8 , cytotoxicity , lysis , in vitro , medicine , immunology , chemistry , immune system , biology , microbiology and biotechnology , antifungal , biochemistry
Liposomal amphotericin B was immunosuppressive on target cell lysis in vitro and on protection mediated by cytotoxic CD8 T cells in murine listeriosis. When dosages usually used for therapy in humans were compared, the immunosuppressive effect of 5 mg of liposomal amphotericin B/kg of body weight/day was similar to that of standard amphotericin B at 1 mg/kg/day, but a dosage of liposomal amphotericin B of 1 mg/kg/day was not suppressive in vivo.
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