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Mycobacterium tuberculosis antigen 85 is induced in vitro by isoniazid (INH); its sustained induction in sputum during tuberculosis (TB) therapy predicts relapse. In this trial, rifampin or rifalazil inhibited the induction of sputum antigen 85 by INH in a dose-dependent fashion. This approach may facilitate the evaluation of new TB drugs.

antimicrobial agents and chemotherapy

Inhibition of Isoniazid-Induced Expression of <i>Mycobacterium tuberculosis</i> Antigen 85 in Sputum: Potential Surrogate Marker in Tuberculosis Chemotherapy Trials

Inhibition of Isoniazid-Induced Expression of Mycobacterium tuberculosis Antigen 85 in Sputum: Potential Surrogate Marker in Tuberculosis Chemotherapy Trials