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The synergism of voriconazole (VRC) and terbinafine was studied by using 39 genotypically defined clinical Candida albicans isolates that were cross-resistant to fluconazole and VRC and serial isolates that gradually developed azole resistance. Synergy was noticed in 100% (eight of eight) of the strains that were resistant to VRC. Antagonism was not observed.

antimicrobial agents and chemotherapy

Synergism of Voriconazole and Terbinafine against <i>Candida albicans</i> Isolates from Human Immunodeficiency Virus-Infected Patients with Oropharyngeal Candidiasis

Synergism of Voriconazole and Terbinafine against Candida albicans Isolates from Human Immunodeficiency Virus-Infected Patients with Oropharyngeal Candidiasis