Open AccessEffects of Single Oral Doses of Gemifloxacin (320 Milligrams) versus Trovafloxacin (200 Milligrams) on Fecal Flora in Healthy Volunteers
Author(s) -
Gloria Garcı́a-Calvo,
Ana Molleja,
Marı́a José Giménez,
Araceli Parra,
Eva Nieto,
Carmen Ponte,
Lorenzo Aguilar,
Francisco Soriano
Publication year - 2001
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.45.2.608-611.2001
Subject(s) - trovafloxacin , gemifloxacin , feces , crossover study , microbiology and biotechnology , antibacterial agent , medicine , fecal coliform , pharmacology , antibiotics , biology , ecology , alternative medicine , pathology , water quality , placebo
Gemifloxacin and trovafloxacin were administered to 12 volunteers in a randomized crossover trial with a 2-week washout period. Stool samples were collected predose and 1, 2, and 3 days postdose. Both quinolones reduced the number of organisms of the family Enterobacteriaceae and aerobic gram-positive organisms. Escherichia coli reduction was greater with gemifloxacin than with trovafloxacin, with postdose isolation of quinolone-resistant strains for which MICs of trovafloxacin were higher than those of gemifloxacin.