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Poly(DL-lactide-co-glycolide) (PLG) microparticles were developed as carriers for isoniazid and rifampin in order to improve compliance of tuberculous chemotherapy. Antitubercular drugs encapsulated in PLG polymers and injected in a single dose subcutaneously resulted in a sustained release (up to 6 weeks) of drugs in various organs of mice. Further, Mycobacterium tuberculosis H(37)Rv-infected animals given a single shot of chemotherapy in PLG microparticles exhibited a better or equivalent clearance of CFU in various organs compared to those given a daily administration of free drugs.

antimicrobial agents and chemotherapy

Therapeutic Efficacy of Poly( <scp>dl</scp> -Lactide-Co-Glycolide)-Encapsulated Antitubercular Drugs against <i>Mycobacterium tuberculosis</i> Infection Induced in Mice

Therapeutic Efficacy of Poly( dl -Lactide-Co-Glycolide)-Encapsulated Antitubercular Drugs against Mycobacterium tuberculosis Infection Induced in Mice