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The antibiotic era began with the discovery, in 1939 and 1940, of the first three significant antibiotics, namely, tyrothricin (of bacterial origin), penicillin (a rediscovery of an antibiotic of fungal origin), and actinomycin (a product of actinomycetes). Within the first 18 years of the antibiotic era, about 30 antimicrobial agents had come into use, as noted by Selman Waksman, the discoverer of streptomycin (20). Included among these, in addition to streptomycin, were chloramphenicol, chlortetracycline, oxytetracycline, bacitracin, erythromycin, novobiocin, oleandomycin, vancomycin, and antimycotic agents such as nystatin and griseofulvin.

Impact of Antimicrobial Agents and Chemotherapy from 1972 to 1998