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The distribution of insertion sequence-like element IS1272 was analyzed for clinical isolates ofStaphylococcus aureus ,Staphylococcus epidermidis , andStaphylococcus haemolyticus . In each of the staphylococcal species, IS1272 was detected in both methicillin-resistant (MR) and methicillin-susceptible strains of different genetic types. In MR isolates, IS1272 was generally located downstream of the truncatedmecR1 gene (ΔmecR1 ), with an identical junction sequence occurring between ΔmecR1 and IS1272 , although insertion of an additional gene sequence in the junction sequence was detected in oneS. epidermidis isolate. These findings suggest that themec element with the rearranged form ofmecR1 (ΔmecR1 -IS1272 ) has been transmitted to multiple clones of staphylococci.

antimicrobial agents and chemotherapy

Distribution of Insertion Sequence-Like Element IS <i>1272</i> and Its Position Relative to Methicillin Resistance Genes in Clinically Important Staphylococci

Distribution of Insertion Sequence-Like Element IS 1272 and Its Position Relative to Methicillin Resistance Genes in Clinically Important Staphylococci