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Parts ofkatG andrpoB from 27 RussianMycobacterium tuberculosis isolates were sequenced to detect mutations causing resistance to isoniazid (INH) and rifampin (RMP), respectively. All 24 INH-resistant isolates had a mutatedkatG , and 22 of them (91.7%) carried a mutation coding for a Ser315Thr shift. AnrpoB mutation was noted for each of the 21 RMP-resistant isolates, with Ser531Leu being the most prevalent change encoded. Only two isolates had identical IS6110 fingerprints.

antimicrobial agents and chemotherapy

A Ser315Thr Substitution in KatG Is Predominant in Genetically Heterogeneous Multidrug-Resistant <i>Mycobacterium tuberculosis</i> Isolates Originating from the St. Petersburg Area in Russia

A Ser315Thr Substitution in KatG Is Predominant in Genetically Heterogeneous Multidrug-Resistant Mycobacterium tuberculosis Isolates Originating from the St. Petersburg Area in Russia