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In vitro comparisons demonstrated that the efficacy of albendazole, albendazole-sulfoxide, and albendazole-sulfone against pathogenic Encephalitozoon species was proportional to the degree of oxidation at a concentration of &gt;10(-3) microgram/ml. Furthermore, at a concentration of &lt;10(-2) microgram/ml, benzimidazoles were more effective against Encephalitozoon cuniculi and Encephalitozoon hellem than against Encephalitozoon intestinalis.

antimicrobial agents and chemotherapy

In Vitro Susceptibilities of the Microsporidia Encephalitozoon cuniculi , Encephalitozoon hellem , and Encephalitozoon intestinalis to Albendazole and Its Sulfoxide and Sulfone Metabolites