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Current therapy for leishmaniasis is unsatisfactory because parenteral antimonial salts and pentamidine are associated with significant toxicity and failure rates. We examined the efficacy of KY62, a new, water-soluble, polyene antifungal, against cutaneous infection withLeishmania amazonensis and against visceral infection withLeishmania donovani in susceptible BALB/c mice. Mice were infected withL. amazonensis promastigotes in the ear pinna and in the tail and were treated with KY62 or amphotericin B. The cutaneous lesions showed a remarkable response to therapy with KY62 at a dose of 30 mg per kg of body weight per day. At this dose, the efficacy of KY62 was equivalent to or better than that of amphotericin B at 1 to 5 mg/kg/day. Mice infected intravenously with 107 L. donovani promastigotes and treated with KY62 showed a 4-log reduction in the parasite burden in the liver and spleen compared to untreated mice. These studies indicate potent activity of KY62 against experimental cutaneous leishmaniasis caused byL. amazoniensis and against experimental visceral leishmaniasis caused byL. donovani .

antimicrobial agents and chemotherapy

Efficacies of KY62 against <i>Leishmania amazonensis</i> and <i>Leishmania donovani</i> in Experimental Murine Cutaneous Leishmaniasis and Visceral Leishmaniasis

Efficacies of KY62 against Leishmania amazonensis and Leishmania donovani in Experimental Murine Cutaneous Leishmaniasis and Visceral Leishmaniasis