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We report on the identification of mutations associated with streptomycin resistance in Mycobacterium tuberculosis. Two isolates (3656 and 3976) showed a wild-type ribosomal protein, S12, but exhibited a single point mutation at 16S rRNA position 491 (C--&gt;T) or 512 (C--&gt;T), respectively. Sequence analysis of a third isolate (2438) revealed a single base change at 16S rRNA position 904 (A--&gt;G). This position is equivalent to invariant position 913 of the Escherichia coli 16S rRNA gene, an A--&gt;G transition of which has been shown previously to impair streptomycin binding and streptomycin-induced misreading in vivo. Surprisingly, strain 2438 harbors an additional mutation in the ribosomal protein S12 (Lys-88--&gt;Gln).

Genetic alterations in streptomycin-resistant Mycobacterium tuberculosis: mapping of mutations conferring resistance