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In vitro susceptibility of Mycobacterium leprae to two bipyridyl analogs was studied by using two biochemical parameters to measure the metabolic activity of the organism. VUF-8514 at 0.16 micrograms/ml, but not VUF-8842, completely inhibited the metabolic activity of M. leprae, and the action was bactericidal. When compared to rifampin (MIC 0.3 micrograms/ml), VUF-8514 was equally bactericidal against M. leprae.

In vitro activities of 2,2'-bipyridyl analogs against Mycobacterium leprae