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Deacylketoconazole was 15- to 50-fold more active against Plasmodium falciparum than was ketoconazole, based on [(3)H]hypoxanthine uptake and quantitative parasite counts. In contrast, there were no significant differences between these drugs in their activity against clinical isolates of Candida spp.

Activity of Ketoconazole and Its Deacyl Derivative Against Plasmodium falciparum and Candida Isolates