English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

An antibiotic-producing bacterium repeatedly isolated from human feces was characterized by standard bacteriological methods. The bacterium is a gram-positive bacillus possessing morphological and physiological features similar to those of Bacillus subtilis, except that it lacks temperature-resistant spore formation and has peritrichous flagella. The cell-free antibiotic produced by the organism in vitro was effective against some gram-negative and gram-positive bacteria and yeast in minimum inhibitory concentration and antibiotic disk assays. The 1,200-dalton antibiotic had an optimal activity against Proteus vulgaris within the pH range of 5.7 to 6.8. The activity was totally destroyed by digestion with pronase and trypsin but was resistant to pepsin, chymotrypsin, papain, and nuclease digestion. In addition, the antibiotic activity against P. vulgaris was stable between pH 3 to 9 and within the temperature range of 20 to 100 degrees C when tested in the fermentation medium. The activity was only partially retained by membrane filters which normally retain globular proteins of molecular weights between 500 to 10,000. Electrophoresis in phosphate buffer indicated that the activity against P. vulgaris had an isoelectric point of approximately 6.45. These properties are compatible with the antibiotic activity associated with a small peptide.

Identification of an Antibiotic-Producing Bacterium from the Human Intestinal Tract and Characterization of Its Antimicrobial Product