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Totals of 8.7% (103/1,190) and 21.0% (249/1,190) of theStreptococcus pneumoniae isolates recovered from specimens collected in the United States during the 2011-2012 AWARE (A ssessingW orldwideA ntimicrobialR esistanceE valuation) Surveillance Program were ceftriaxone nonsusceptible according to the CLSI (≤1 μg/ml for susceptible) and EUCAST (≤0.5 μg/ml for susceptible) criteria, respectively. Decreased susceptibility to ceftriaxone (MIC, 1 μg/ml) was frequently observed among serotypes 19A (51.4%; 128/249) and 35B (29.7%; 74/249), which were most often observed in the East South Central and South Atlantic U.S. Census regions. Ceftaroline (MIC50/90 , 0.12/0.25 μg/ml) remained active (≥96.8% susceptible) when tested against these less susceptible isolates.

antimicrobial agents and chemotherapy

Decreased Ceftriaxone Susceptibility in Emerging (35B and 6C) and Persisting (19A) Streptococcus pneumoniae Serotypes in the United States, 2011-2012: Ceftaroline Remains Active <i>In Vitro</i> among β-Lactam Agents

Decreased Ceftriaxone Susceptibility in Emerging (35B and 6C) and Persisting (19A) Streptococcus pneumoniae Serotypes in the United States, 2011-2012: Ceftaroline Remains Active In Vitro among β-Lactam Agents