Open AccessEvaluation of the In Vitro Activity of Ceftazidime-Avibactam and Ceftolozane-Tazobactam against Meropenem-Resistant Pseudomonas aeruginosa Isolates
Author(s) -
Deanna J. Buehrle,
Ryan K. Shields,
Liang Chen,
Binghua Hao,
Ellen G. Press,
Ammar Alkrouk,
Brian A. Potoski,
Barry N. Kreiswirth,
Cornelius J. Clancy,
M. Hong Nguyen
Publication year - 2016
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.02969-15
Subject(s) - ceftazidime/avibactam , meropenem , cefepime , ceftazidime , tazobactam , microbiology and biotechnology , pseudomonas aeruginosa , avibactam , biology , piperacillin , medicine , antibiotics , bacteria , antibiotic resistance , genetics
We compared ceftazidime-avibactam, ceftolozane-tazobactam, ceftazidime, cefepime, and piperacillin-tazobactam MICs for 38 meropenem-resistant Pseudomonas aeruginosa isolates. No isolates harbored carbapenemases; 74% were oprD mutants. Ceftazidime-avibactam and ceftolozane-tazobactam were active against 92% of the isolates, including 80% that were resistant to all three β-lactams. Forty-three percent of ceftazidime-avibactam-susceptible isolates and 6% of ceftolozane-tazobactam-susceptible isolates exhibited MICs at the respective breakpoints. Ceftolozane-tazobactam and ceftazidime-avibactam are therapeutic options for meropenem-resistant P. aeruginosa infections that should be used judiciously to preserve activity.
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