Open AccessIMP-27, a Unique Metallo-β-Lactamase Identified in Geographically Distinct Isolates of Proteus mirabilis
Author(s) -
Nyssa Dixon,
Randal C. Fowler,
Ayumi Yoshizumi,
Tsukasa Horiyama,
Yoshikazu Ishii,
Lucas B. Harrison,
Chelsie N. Geyer,
Ellen Smith Moland,
Kenneth S. Thomson,
Nancy D. Hanson
Publication year - 2016
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.02945-15
Subject(s) - proteus mirabilis , ceftazidime , aztreonam , microbiology and biotechnology , ertapenem , biology , piperacillin , integron , tazobactam , antibiotics , antibiotic resistance , imipenem , gene , bacteria , genetics , escherichia coli , pseudomonas aeruginosa
A novel metallo-β-lactamase gene, blaIMP-27, was identified in unrelated Proteus mirabilis isolates from two geographically distinct locations in the United States. Both isolates harbor blaIMP-27 as part of the first gene cassette in a class 2 integron. Antimicrobial susceptibility testing indicated susceptibility to aztreonam, piperacillin-tazobactam, and ceftazidime but resistance to ertapenem. However, hydrolysis assays indicated that ceftazidime was a substrate for IMP-27.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom