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A novel series of thirty-one N-substituted urea, thiourea, and selenourea derivatives containing diphenyldiselenide entities were synthesized, fully characterized by spectroscopic and analytical methods, and screened for theirin vitro leishmanicidal activities. The cytotoxic activity of these derivatives was tested againstLeishmania infantum axenic amastigotes, and selectivity was assessed in human THP-1 cells.

Synthesis and Leishmanicidal Activity of Novel Urea, Thiourea, and Selenourea Derivatives of Diselenides