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Thein vitro susceptibilities of 24 molecularly identified dimorphic fungi belonging to the generaAdiaspiromyces ,Blastomyces , andEmergomyces within the familyAjellomycetaceae were tested against 8 standard antifungal agents using CLSI document M38-A2. Amphotericin B and posaconazole had the lowest geometric mean MICs (&lt;0.05 μg/ml) followed by itraconazole (&lt;0.07 μg/ml), voriconazole (&lt;0.15 μg/ml), and isavuconazole (&lt;0.42 μg/ml) while fluconazole was not active. Micafungin demonstrated goodin vitro antifungal activity againstEmergomyces (geometric mean minimum effective concentration [GM MEC] 0.1 μg/ml) andBlastomyces (GM MEC &lt;0.017 μg/ml).

Antifungal Susceptibility of Emerging Dimorphic Pathogens in the Family Ajellomycetaceae