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Decreased susceptibility to chlorhexidine gluconate (CHDN) in methicillin-resistant Staphylococcus aureus (MRSA) is associated with the qacA, qacB, and smr genes, encoding efflux pumps. A total of 334 MRSA isolates were collected from two Canadian intensive care units between 2005 and 2009. We identified the qacAB genes in 7 strains (2%; 2 qacA genes and 5 qacB genes) and the smr gene in 23 (7%) strains. CHDN minimal bactericidal concentrations were slightly higher for strains harboring smr genes.

antimicrobial agents and chemotherapy

Distribution of Antiseptic Resistance Genes <i>qacA, qacB</i> , and <i>smr</i> in Methicillin-Resistant Staphylococcus aureus Isolated in Toronto, Canada, from 2005 to 2009

Distribution of Antiseptic Resistance Genes qacA, qacB , and smr in Methicillin-Resistant Staphylococcus aureus Isolated in Toronto, Canada, from 2005 to 2009