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Screening of 368 consecutive nonreplicate clinical isolates of Enterobacteriaceae resistant to nalidixic acid and at least one extended-spectrum beta-lactam revealed the presence of qnrA, qnrB, and qnrS determinants, and identified novel qnrB variants, in Citrobacter freundii isolates. This study also revealed, for the first time, the linkage of qnrB, armA, and extended-spectrum and/or AmpC-type beta-lactamase genes on large conjugative plasmids.

antimicrobial agents and chemotherapy

Plasmid-Mediated Quinolone Resistance Determinants qnrA , qnrB , and qnrS among Clinical Isolates of Enterobacteriaceae in a Korean Hospital