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Biofilm-associated infections caused byAcinetobacter baumannii are extremely recalcitrant to antibiotic treatment. We report thatA. baumannii develops a mature biofilm when grown in complement-free human serum (HS). We demonstrate that 16 μM gallium nitrate (GaN) drastically reducesA. baumannii growth and biofilm formation in HS, whereas 64 μM GaN causes massive disruption of preformedA. baumannii biofilm. These findings pave the way to the repurposing of GaN as an antibiofilm agent forA. baumannii .

Acinetobacter baumannii Biofilm Formation in Human Serum and Disruption by Gallium