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Twenty-five AIDS patients were treated with HE2000, a synthetic adrenal hormone. The drug was well tolerated and safe and reduced both the incidence of tuberculosis coinfection by 42.2% (P &lt; 0.05) and the cumulative incidence of opportunistic infections (P &lt; 0.05). These results warrant further clinical investigation of HE2000.

Safety and Activity of the Immune Modulator HE2000 on the Incidence of Tuberculosis and Other Opportunistic Infections in AIDS Patients