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TwoEscherichia coli clones (sequence type 648 [ST648] and ST156) that coproduce NDM-5 and MCR-1 were detected from a single fowl in China. Thebla NDM-5 gene was found on the two indistinguishable IncX3 plasmids from the two differentE. coli isolates, whereas themcr-1 gene was located on IncHI2 and IncI2 plasmids, respectively, suggesting thatbla NDM-5 andmcr-1 have spread in avian intestinal flora. Also, the two strains harborbla TEM-1 ,bla CTX-M-55 ,fosA3 , andaac(6 ′)-Ib . The multiresistantE. coli strains (especially the epidemic clone ST648) might raise a potential threat to human health via food chain transmission.

Emergence of NDM-5- and MCR-1-Producing Escherichia coli Clones ST648 and ST156 from a Single Muscovy Duck (Cairina moschata)