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We investigated the utility of radioimmunotherapy (RIT) in the treatment of experimental cryptococcal infection with high-inoculum and the possibility of RIT treatment selecting for fungal cells with radiation-resistant phenotypes. RIT reduced mortality in high-burden infections, and we found no evidence for the development of radiation-resistant cells.

antimicrobial agents and chemotherapy

Radioimmunotherapy Is Effective against High-Inoculum <i>Cryptococcus neoformans</i> Infection in Mice and Does Not Select for Radiation-Resistant Cryptococcal Cells

Radioimmunotherapy Is Effective against High-Inoculum Cryptococcus neoformans Infection in Mice and Does Not Select for Radiation-Resistant Cryptococcal Cells