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SCY-078in vitro activity was determined for 178 isolates of resistant or susceptibleCandida albicans ,Candida dubliniensis ,Candida glabrata ,Candida krusei ,Candida lusitaniae , andCandida parapsilosis , including 44Candida isolates with known genotypic (FKS1 orFKS2 mutations), phenotypic, or clinical resistance to echinocandins. Results were compared to those for anidulafungin, caspofungin, micafungin, fluconazole, and voriconazole. SCY-078 was shown to have excellent activity against both wild-type isolates and echinocandin- and azole-resistant isolates ofCandida species.

Antifungal Activity of SCY-078 and Standard Antifungal Agents against 178 Clinical Isolates of Resistant and Susceptible Candida Species