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We determined thein vitro interactions between echinocandins and azoles against 10 multidrug-resistantCandida auris strains by use of a microdilution checkerboard technique. Our results suggest synergistic interactions between micafungin and voriconazole with fractional inhibitory concentration index (FICI) values of 0.15 to 0.5, and we observed indifferent interactions when micafungin was combined with fluconazole (FICI, 0.62 to 1.5). Combinations of caspofungin with fluconazole or voriconazole exhibited indifferent interactions. No antagonism was observed for any combination.

In Vitro Interactions of Echinocandins with Triazoles against Multidrug-Resistant Candida auris